Per1 - period circadian regulator 1 Gene

Also Known as rper1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287422

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]

Per1 Products (1)

mRNA Protein Name
NM_001034125.1 NP_001029297.1 period circadian protein homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11597585 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12176169 RGD
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
11122332 RGD
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
24447840 RGD
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
24447840 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
20589906 RGD
involved in regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
24447840 RGD
involved in regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
24447840 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
22356123 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 1

  • circadian clock protein PERIOD 1

  • period 1

  • period circadian clock 1

  • period homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125145 AA92593 Antagonist 99.94% Unkown
HY-N10987 Spiranthesol / Unkown
HY-N18371 Decumbenine / Unkown
HY-RS10331 PER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19930 Per1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26432 Per1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Per1 NCBI NCBI:5187