Eif5a - eukaryotic translation initiation factor 5A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287444

Summary

Predicted to enable U6 snRNA binding activity; protein N-terminus binding activity; and translation elongation factor activity. Involved in several processes, including cellular response to thyroid hormone stimulus; positive regulation of Reactive Oxygen Species metabolic process; and regulation of apoptotic process. Located in dendrite and neuronal cell body. Is active in synapse. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A). [provided by Alliance of Genome Resources, Apr 2022]

Eif5a Products (2)

mRNA Protein Name
NM_001033681.2 NP_001028853.1 eukaryotic translation initiation factor 5A-1
NM_001033681.2 NP_001028853.1 eukaryotic translation initiation factor 5A-1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to thyroid hormone stimulus IEP
IEP: Inferred from expression pattern
22667453 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9396730 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20930373 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
20930373 RGD
involved in positive regulation of muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19006180 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20930373 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
18606156 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18606156 RGD
is active in synapse EXP
EXP: Inferred from Experiment
14532281 RGD
is active in synapse IDA
IDA: Inferred from direct assay
14532281 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5A-1

  • eIF-4D

  • eIF-5A

  • eIF-5A-1

  • eIF-5A1

  • eukaryotic initiation factor 5A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2397 9''-Methyl salvianolate B 99.54% Unkown
HY-111522 RK-9123016 Inhibitor 99.65% Unkown
HY-106801 Girolline / Unkown
HY-RS04286 EIF5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W141446 VT00065 Inhibitor ≥98.0% Unkown
HY-121722 Deoxyhypusine / Unkown
HY-122039 Hypusine dihydrochloride / Unkown
HY-RS04285 EIF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04287 EIF5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126171 Hypusine / Unkown
HY-RS19060 Eif5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19678 Eif5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25550 Eif5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26171 Eif5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif5a NCBI NCBI:1984