Cr2 - complement C3d receptor 2 Gene

Predicted to enable several functions, including complement binding activity; Complement Receptor activity; and protein homodimerization activity. Predicted to be involved in B cell differentiation; B cell proliferation; and negative regulation of complement activation, classical pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in several cellular components, including cell surface; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]