Grn - granulin precursor Gene

Also Known as PEPI; PGRN

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29143

Summary

Predicted to enable chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to be located in several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Predicted to be active in extracellular region. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Apr 2022]

Grn Products (2)

mRNA Protein Name
NM_001145842.1 NP_001139314.1 progranulin isoform b precursor
NM_017113.2 NP_058809.2 progranulin isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17307734 RGD
Biological Process GO Annotation Evidence References Source
involved in chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
17307734 RGD
involved in male mating behavior IMP
IMP: Inferred from mutant phenotype
10764901 RGD
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
17179653 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
21813674 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
21813674 RGD
involved in response to estradiol IDA
IDA: Inferred from direct assay
17179653 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
21813674 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24046442 RGD
is active in synapse IDA
IDA: Inferred from direct assay
24046442 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

progranulin

  • acrogranin

  • epithelin

  • granulins

  • proepithelin

  • prostate cancer cell-derived growth factor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12854 Imetelstat 99.43% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P4073 ANG1005 98.83% Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99688 Latozinemab Inhibitor 96.03% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115733 Cathepsin L-IN-2 Inhibitor 98.02% Unkown
HY-RS17678 Grn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05843 GRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124393 GRN-529 Modulator / Unkown
HY-RS24139 Grn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grn NCBI NCBI:2896