Capn1 - calpain 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29153

Summary

Enables several functions, including calcium ion binding activity; calcium-dependent cysteine-type endopeptidase activity; and cytoskeletal protein binding activity. Involved in several processes, including negative regulation of NIK/NF-kappaB signaling; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of leukocyte tethering or rolling. Located in cytosol; membrane; and mitochondrion. Biomarker of acute kidney failure; aortic atherosclerosis; epilepsy; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]

Capn1 Products (1)

mRNA Protein Name
NM_019152.2 NP_062025.1 calpain-1 catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
11893336 RGD
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
17429681 RGD
enables calcium-dependent cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
11893336 RGD
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
17429681 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
20850499 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18559257 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hydrogen peroxide IMP
IMP: Inferred from mutant phenotype
22402252 RGD
involved in negative regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
25653381 RGD
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21415394 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22402252 RGD
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
21415394 RGD
involved in positive regulation of vascular permeability IMP
IMP: Inferred from mutant phenotype
21415394 RGD
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
17182728 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
17429681 RGD
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
11893336 RGD
involved in protein catabolic process at postsynapse EXP
EXP: Inferred from Experiment
10825658 RGD
involved in protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
10825658 RGD
involved in protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
10825658 RGD
involved in protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
24285894 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
22711986 RGD
involved in response to angiotensin IMP
IMP: Inferred from mutant phenotype
21415394 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
24641850 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10688895 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10688895 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
10688895 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
10688895 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
2843999 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
2843999 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-1 catalytic subunit

  • CANP 1

  • calcium-activated neutral proteinase 1

  • calpain 1, (mu/I) large subunit

  • calpain mu-type

  • calpain-1 large subunit

  • micromolar-calpain

  • muCANP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-RS01883 CAPN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01895 CAPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17903 Capn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24372 Capn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn1 NCBI NCBI:823