Hfe - homeostatic iron regulator Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29199

Summary

Predicted to enable beta-2-microglobulin binding activity; co-receptor binding activity; and Transferrin Receptor binding activity. Involved in several processes, including acute-phase response; liver regeneration; and response to starvation. Located in apical part of cell; plasma membrane; and terminal web. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple); arthritis (multiple); bone marrow Cancer (multiple); hemochromatosis (multiple); and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator). [provided by Alliance of Genome Resources, Apr 2022]

Hfe Products (6)

mRNA Protein Name
NM_001173434.1 NP_001166905.1 hereditary hemochromatosis protein homolog isoform 2 precursor
NM_001173435.1 NP_001166906.1 hereditary hemochromatosis protein homolog isoform 3 precursor
NM_053301.4 NP_445753.1 hereditary hemochromatosis protein homolog isoform 1 precursor
NM_001173434.1 NP_001166905.1 hereditary hemochromatosis protein homolog isoform 2 precursor
NM_001173435.1 NP_001166906.1 hereditary hemochromatosis protein homolog isoform 3 precursor
NM_053301.4 NP_445753.1 hereditary hemochromatosis protein homolog isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
22469696 RGD
involved in cellular response to iron ion starvation IEP
IEP: Inferred from expression pattern
16208485 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
15082582 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22364558 RGD
involved in multicellular organismal-level iron ion homeostasis IEP
IEP: Inferred from expression pattern
15082582 RGD
involved in response to iron ion starvation IEP
IEP: Inferred from expression pattern
16208485 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16208485 RGD
NOT located in microvillus membrane IDA
IDA: Inferred from direct assay
16208485 RGD
located in terminal web IDA
IDA: Inferred from direct assay
16208485 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hereditary hemochromatosis protein homolog

  • RT1-CAFE

  • hemochromatosis

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06149 HFE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18894 Hfe Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25385 Hfe Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992072 Anti-Human/Mouse CD95 Antibody (HFE7A) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hfe NCBI NCBI:3077