CXCL3 - C-X-C motif chemokine ligand 3 Gene

Also Known as GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2921

About CXCL3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,036,589-74,038,689 (from NCBI)

This gene has 4 transcripts (splice variants), 13 orthologues and 12 paralogues. Biased expression in appendix (RPKM 8.6), bone marrow (RPKM 6.3) and 12 other tissues.

Summary

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

CXCL3 Products (1)

mRNA Protein Name
NM_002090.3 NP_002081.2 C-X-C motif chemokine 3 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12949249 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12949249 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10095777 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCL3 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (40 - 99)

  • 0
  • 100
  • 107 a.a.
Protein Preferred Names Protein Names

C-X-C motif chemokine 3

  • GRO-gamma

Recombinant CXCL3 Proteins

Cat. No. Product Name Accession Purity
HY-P7192 GRO-gamma/CXCL3 Protein, Human (CHO) P19876 (A35-N107) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7193 GRO-gamma/CXCL3 Protein, Human P19876 (A35-N107) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72678 GRO-gamma/CXCL3 Protein, Human (His) P19876 (A35-N107) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72678AF Animal-Free GRO-gamma/CXCL3 Protein, Human (His) P19876 (A35-N107) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03392 CXCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110268 NVP CXCR2 20 Antagonist / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate / Unkown
HY-RS17078 Cxcl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23522 Cxcl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others CXCL3 NCBI