CLCN2 - Clcn2 chloride voltage-gated channel 2 Gene

Also Known as ClC-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29232

Summary

Enables voltage-gated Chloride Channel activity. Involved in chloride transport and lung development. Located in dendrite and perikaryon. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

CLCN2 Products (1)

mRNA Protein Name
NM_017137.2 NP_058833.1 chloride channel protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
1311421 RGD
enables voltage-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
1334533 RGD
enables voltage-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
22405205 RGD
enables volume-sensitive chloride channel activity IMP
IMP: Inferred from mutant phenotype
1334533 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular hypotonic response IMP
IMP: Inferred from mutant phenotype
1334533 RGD
involved in chloride transport IDA
IDA: Inferred from direct assay
1311421 RGD
involved in lung development IMP
IMP: Inferred from mutant phenotype
14711803 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
29344669 RGD
involved in positive regulation of voltage-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
29344669 RGD
involved in regulation of membrane depolarization during action potential IMP
IMP: Inferred from mutant phenotype
8816717 RGD
Cellular Component GO Annotation Evidence References Source
located in astrocyte end-foot IDA
IDA: Inferred from direct assay
11068136 RGD
located in axon initial segment IDA
IDA: Inferred from direct assay
11068136 RGD
located in dendrite IDA
IDA: Inferred from direct assay
12967985 RGD
located in dendritic spine membrane IDA
IDA: Inferred from direct assay
11068136 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
12967985 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chloride channel protein 2

  • chloride channel 2

  • chloride channel, voltage-sensitive 2

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0680 Lubiprostone (hemiketal) Activator 98.00% Unkown

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02754 CLCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22442 Clcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28965 Clcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CLCN2 NCBI NCBI:1181