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Drd3 - dopamine receptor D3 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29238

About Drd3

Primary_assembly 11: 56,879,689-56,940,596 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 206 orthologues, 35 paralogues and is associated with 27 phenotypes. Restricted expression toward (RPKM 1.9).

Summary

Enables D1 Dopamine Receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting Dopamine Receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 Products (1)

mRNA	Protein	Name
NM_017140.2	NP_058836.1	D(3) dopamine receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	14732731	RGD
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IDA: Inferred from direct assay	1975644	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14499480	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	14617818	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	14617818	RGD
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15265811	RGD
involved in acid secretion	IDA IDA: Inferred from direct assay	8302280	RGD
involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	8302280	RGD
involved in autophagy	IMP IMP: Inferred from mutant phenotype	26649942	RGD
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	16026479	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	25989500	RGD
involved in negative regulation of sodium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	15265811	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16902178	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15584906	RGD
involved in positive regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	8302280	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16902178	RGD
involved in regulation of circadian sleep/wake cycle, sleep	IMP IMP: Inferred from mutant phenotype	15913875	RGD
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	16490190	RGD
involved in regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	22394078	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	16510729	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	16510729	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	16510729	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	1975644	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	16510729	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	16510729	RGD
located in apical part of cell	IDA IDA: Inferred from direct assay	9822449	RGD
located in cell projection	IDA IDA: Inferred from direct assay	15584906	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	14617818	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23001156	RGD
located in membrane	IDA IDA: Inferred from direct assay	8302280	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	23001156	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd3 Protein Structure

7tmA_D3_dopamine_R

0
100
200
300
400
446 a.a.

Protein Preferred Names	Protein Names
D(3) dopamine receptor	dopaminergic receptor D3

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19654	GSK598809	Antagonist	99.73%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19654C	(-)-GSK598809 hydrochloride	Antagonist	98.66%	Unkown
HY-19654B	(-)-GSK598809	Antagonist	/	Unkown
HY-RS04000	DRD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04001	Drd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04002	Drd3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd3	NCBI	NCBI:1814