2. Gene
  3. Drd3 - dopamine receptor D3 Gene

Drd3 - dopamine receptor D3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29238 | Gene type: protein coding

About Drd3

Primary_assembly 11: 56,879,689-56,940,596 reverse strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 206 orthologues, 35 paralogues and is associated with 27 phenotypes. Restricted expression toward (RPKM 1.9).

Summary

Enables D1 Dopamine Receptor binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and protein domain specific binding activity. Involved in several processes, including adenylate cyclase-inhibiting Dopamine Receptor signaling pathway; regulation of secretion; and regulation of transcription by RNA polymerase II. Located in several cellular components, including apical part of cell; endocytic vesicle; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane. Used to study Parkinsonism; amnestic disorder; essential tremor; and hypertension. Biomarker of heroin dependence and visual epilepsy. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 Products(1)

mRNA Protein Name
NM_017140.2 NP_058836.1 D(3) dopamine receptor

Drd3 Protein Structure

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (29 - 439)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (30 - 56)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (63 - 86)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (102 - 132)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (149 - 167)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (184 - 209)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (367 - 397)

7tmA_D3_dopamine_R

7tmA_D3_dopamine_R: cd15310 (407 - 432)

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  • 446 a.a.
Protein Preferred Names Protein Names

D(3) dopamine receptor

dopaminergic receptor D3

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19654 GSK598809 Antagonist 99.73% Unkown
HY-19654C (-)-GSK598809 hydrochloride Antagonist 99.64% Unkown
HY-19654B (-)-GSK598809 Antagonist / Unkown
HY-RS04000 DRD3 Human Pre-designed siRNA Set A / Unkown
HY-RS04001 Drd3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04002 Drd3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drd3 NCBI NCBI:1814