GRSF1 - G-rich RNA sequence binding factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2926

About GRSF1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,815,783-70,843,235 (from NCBI)

This gene has 7 transcripts (splice variants), 157 orthologues and 8 paralogues. Ubiquitous expression in adrenal (RPKM 14.1), brain (RPKM 13.8) and 25 other tissues.

Summary

The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GRSF1 Products (2)

mRNA Protein Name
NM_001098477.2 NP_001091947.1 G-rich sequence factor 1 isoform 2
NM_002092.4 NP_002083.4 G-rich sequence factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
29967381 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24338975 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of mitochondrial RNA catabolic process IDA
IDA: Inferred from direct assay
29967381 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
25683715 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
29967381 GOA
located in ribonucleoprotein granule IDA
IDA: Inferred from direct assay
25683715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRSF1 Protein Structure

(152 - 223)

(252 - 320)

(403 - 470)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

G-rich sequence factor 1

GRSF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRSF1 Q12849 PSMD10 Homo sapiens O75832
Anti Tag CoIP
24338975
Cross: Cross-species interaction Intra: Intraspecies interaction

GRSF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83210 GRSF1 Antibody (YA2955) WB, ICC/IF Human
HY-P83210A GRSF1 Antibody (YA2955)(PBS only) WB, ICC/IF Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05848 GRSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22541 Grsf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29061 Grsf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GRSF1 VGNC VGNC:29667
Mus musculus GRSF1 MGD MGI:106479
Canis familiaris GRSF1 VGNC VGNC:51773
Macaca mulatta GRSF1 VGNC VGNC:73296
Felis catus GRSF1 VGNC VGNC:67485
Rattus norvegicus GRSF1 RGD RGD:1310858
Others GRSF1 NCBI