Tyms - thymidylate synthetase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29261

About Tyms

Primary_assembly 9: 113,313,452-113,329,536 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 38 phenotypes. Biased expression in Thymus (RPKM 144.9), Spleen (RPKM 129.1) and 9 other tissues.

Summary

Enables several functions, including folic acid binding activity; protein homodimerization activity; and Thymidylate Synthase activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; response to steroid hormone; and response to vitamin. Located in mitochondrion and nucleolus. Used to study urinary bladder Cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]

Tyms Products (1)

mRNA Protein Name
NM_019179.2 NP_062052.1 thymidylate synthase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables folic acid binding IDA
IDA: Inferred from direct assay
7537805 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
9894005 RGD
enables mRNA binding IPI
IPI: Inferred from physical interaction
9891091 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9894005 RGD
enables thymidylate synthase activity IDA
IDA: Inferred from direct assay
9894005 RGD
Biological Process GO Annotation Evidence References Source
involved in cartilage development IEP
IEP: Inferred from expression pattern
3471366 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
19628084 RGD
involved in dTMP biosynthetic process IDA
IDA: Inferred from direct assay
9894005 RGD
involved in developmental growth IEP
IEP: Inferred from expression pattern
7471094 RGD
involved in intestinal epithelial cell maturation IEP
IEP: Inferred from expression pattern
1260861 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
2707640 RGD
involved in pyrimidine nucleobase metabolic process IEP
IEP: Inferred from expression pattern
9524100 RGD
involved in regulation of translation IDA
IDA: Inferred from direct assay
26315778 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
9524100 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9305788 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
9528665 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
2707640 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
9683817 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
9635926 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
8781506 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
10395942 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
7686361 RGD
involved in tetrahydrofolate metabolic process IEP
IEP: Inferred from expression pattern
7503782 RGD
involved in uracil metabolic process IEP
IEP: Inferred from expression pattern
2043679 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tyms Protein Structure

PTZ00164

PTZ00164: cl36520 (20 - 306)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

thymidylate synthase

  • TS

  • TSase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163538 TYM-3-98 99.56% Unkown
HY-RS15304 TYMS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15305 Tyms Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15306 Tyms Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3764 Diosbulbin C Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyms NCBI NCBI:7298