TYMS - thymidylate synthetase Gene
Also Known as TS; TMS; DKCD; HST422
Species: Homo sapiens
About TYMS
This gene has 6 transcripts (splice variants), 226 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 46.3), testis (RPKM 32.5) and 21 other tissues.
Summary
Thymidylate Synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for Cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial Enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast Cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
TYMS Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001354868.2 | NP_001341797.1 | thymidylate synthase isoform 3 |
| NM_001071.4 | NP_001062.1 | thymidylate synthase isoform 1 |
| NM_001354867.2 | NP_001341796.1 | thymidylate synthase isoform 2 |
| XM_024451242.2 | XP_024307010.1 | thymidylate synthase isoform X1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA regulatory element binding translation repressor activity |
IDA
IDA: Inferred from direct assay
|
1924359 | GOA |
| enables sequence-specific mRNA binding |
IDA
IDA: Inferred from direct assay
|
1924359 | GOA |
| enables thymidylate synthase activity |
IDA
IDA: Inferred from direct assay
|
8845352 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in dTMP biosynthetic process |
IDA
IDA: Inferred from direct assay
|
8845352 | GOA |
| involved in negative regulation of translation |
IDA
IDA: Inferred from direct assay
|
1924359 | GOA |
| involved in response to organophosphorus |
IEP
IEP: Inferred from expression pattern
|
16079077 | GOA |
| involved in tetrahydrofolate interconversion |
IDA
IDA: Inferred from direct assay
|
15093541 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
21876188 | GOA |
| located in mitochondrial inner membrane |
IDA
IDA: Inferred from direct assay
|
21876188 | GOA |
| located in mitochondrial matrix |
IDA
IDA: Inferred from direct assay
|
21876188 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
21876188 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
21876188 | GOA |
TYMS Protein Structure
Thymidylat_synt: Thymidylate synthase (31 - 313)
- 0
- 100
- 200
- 313 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
thymidylate synthase |
|
TYMS Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80973 | Thymidylate Synthase Antibody (YA841) | WB, IHC-F, IHC-P, ICC/IF, FC, IP | Human, Mouse, Rat |
| HY-P80973A | Thymidylate Synthase Antibody (YA841)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, FC, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Internal Hordeolum |
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| Neural Tube Defects |
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| Conjunctival Squamous Cell Carcinoma |
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| Colorectal Cancer |
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| Malaria |
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| Gastric Cancer |
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| Gastroesophageal Reflux |
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| Lung Cancer |
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| Rectum Cancer |
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| Dihydropyrimidine Dehydrogenase Deficiency |
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| Biliary Tract Cancer |
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| Bladder Cancer |
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| Retinoblastoma |
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| Secondary Corneal Edema |
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| Hemifacial Spasm |
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| Mucositis |
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| Colon Adenocarcinoma |
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| Gastrointestinal Carcinoma |
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| Mesothelioma, Malignant |
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| Papilloma |
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| Pleural Cancer |
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| Dyskeratosis Congenita |
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| Squamous Cell Carcinoma, Head And Neck |
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| Pancreatic Cancer |
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| Adult Acute Lymphocytic Leukemia |
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| Subacute Leukemia |
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| Childhood Acute Lymphocytic Leukemia |
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| Breast Cancer |
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| Lynch Syndrome |
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| Hyperhomocysteinemia |
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| Lung Non-Squamous Non-Small Cell Carcinoma |
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| Ovarian Cancer |
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| Neutropenia |
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| Leukemia, Acute Lymphoblastic |
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| Deficiency Anemia |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | TYMS | VGNC | VGNC:36549 |
| Macaca mulatta | TYMS | VGNC | VGNC:78681 |
| Canis familiaris | TYMS | VGNC | VGNC:48025 |
| Felis catus | TYMS | VGNC | VGNC:66737 |
| Mus musculus | TYMS | MGD | MGI:98878 |
| Rattus norvegicus | TYMS | RGD | RGD:3921 |
| Others | TYMS | NCBI |