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Adora1 - adenosine A1 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29290

About Adora1

Primary_assembly 13: 45,658,872-45,695,801 reverse strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 274 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 184.), Spleen (RPKM 61.9) and 8 other tissues.

Summary

Enables several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in several processes, including lipid homeostasis; modulation of chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axon; basolateral plasma membrane; and synaptic membrane. Is active in calyx of Held. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study cerebral infarction; hypertension; lung disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora1 Products (1)

mRNA	Protein	Name
NM_017155.3	NP_058851.2	adenosine receptor A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled adenosine receptor activity	IDA IDA: Inferred from direct assay	9261808	RGD
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	11390975	RGD
enables G-protein beta/gamma-subunit complex binding	IDA IDA: Inferred from direct assay	12764156	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	10866672	RGD
enables heterotrimeric G-protein binding	IDA IDA: Inferred from direct assay	12764156	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11390975	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11390975	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16481441	RGD
enables purine nucleoside binding	IPI IPI: Inferred from physical interaction	11906959	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12764156	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16286581	RGD
involved in cognition	IMP IMP: Inferred from mutant phenotype	19307960	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20065990	RGD
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19942300	RGD
involved in fatty acid homeostasis	IDA IDA: Inferred from direct assay	15220221	RGD
involved in lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19093734	RGD
involved in negative regulation of acute inflammatory response	IDA IDA: Inferred from direct assay	2167912	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12578815	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	16690710	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12021208	RGD
involved in negative regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	19491711	RGD
involved in negative regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	16109808	RGD
involved in negative regulation of glutamate secretion	IDA IDA: Inferred from direct assay	16481441	RGD
involved in negative regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	15044554	RGD
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	15220221	RGD
involved in negative regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	14596853	RGD
involved in negative regulation of neurotrophin production	IMP IMP: Inferred from mutant phenotype	19524026	RGD
NOT involved in negative regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12626609	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	12626609	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	16481441	RGD
involved in negative regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	9597368	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12764156	RGD
involved in positive regulation of blood pressure	IDA IDA: Inferred from direct assay	12234813	RGD
involved in positive regulation of dephosphorylation	IDA IDA: Inferred from direct assay	12234781	RGD
involved in positive regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	19574994	RGD
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	9597368	RGD
involved in positive regulation of nucleoside transport	IDA IDA: Inferred from direct assay	15024061	RGD
involved in positive regulation of peptide secretion	IMP IMP: Inferred from mutant phenotype	16286581	RGD
involved in positive regulation of potassium ion transport	IDA IDA: Inferred from direct assay	9261808	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	8998253	RGD
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	19879903	RGD
involved in regulation of cardiac muscle cell contraction	IDA IDA: Inferred from direct assay	19525381	RGD
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	20334814	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	12963795	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	12963795	RGD
involved in regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	16352472	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	16690710	RGD
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	16352472	RGD
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	15220221	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	12100087	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	16481441	RGD
located in axolemma	IDA IDA: Inferred from direct assay	16481441	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15024061	RGD
is active in calyx of Held	EXP EXP: Inferred from Experiment	12963795	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	12963795	RGD
located in cell body	IDA IDA: Inferred from direct assay	12417330	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12417330	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15044554	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16952160	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	16481441	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	16481441	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16952160	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16481441	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	16952160	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora1 Protein Structure

7tmA_Adenosine_R_A1

0
100
200
300
326 a.a.

Protein Preferred Names	Protein Names
adenosine receptor A1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00391	ADORA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00392	Adora1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00393	Adora1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180879	ADORA1 modulator-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora1	NCBI	NCBI:134