Lrp5 - LDL receptor related protein 5 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 293649

Summary

Predicted to enable Wnt-activated receptor activity; Wnt-protein binding activity; and coreceptor activity involved in Wnt signaling pathway. Involved in response to peptide hormone; response to radiation; and retina vasculature morphogenesis in camera-type eye. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Used to study autosomal dominant polycystic kidney disease and polycystic liver disease. Biomarker of osteonecrosis; osteoporosis; and tendinitis. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Lrp5 Products (1)

mRNA Protein Name
NM_001106321.2 NP_001099791.2 low-density lipoprotein receptor-related protein 5 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15962290 RGD
involved in retina vasculature morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
32833527 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125146 BMD4503-2 99.21% Unkown
HY-RS16292 Lrp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181585 FP1-24 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-RS07800 LRP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169508 BMD4503-1 Modulator / Unkown
HY-RS24282 Lrp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992126 Remigromig Inhibitor / Unkown
HY-P991569 PF-04840082 Antagonist / Unkown
HY-P992263 Anti-LRP5 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp5 NCBI NCBI:4041