Men1 - menin 1 Gene

Also Known as menin

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29417

Summary

Enables chromatin binding activity. Involved in several processes, including animal organ development; regulation of epithelial cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in endocrine gland Cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]

Men1 Products (1)

mRNA Protein Name
NM_019208.3 NP_062081.1 menin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
24157940 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
22166975 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
21239441 RGD
involved in decidualization IEP
IEP: Inferred from expression pattern
19780023 RGD
involved in negative regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
15054094 RGD
involved in negative regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
15054094 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15054094 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22120711 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24157940 RGD
involved in regulation of activin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15031321 RGD
involved in regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
24157940 RGD
involved in response to transforming growth factor beta IMP
IMP: Inferred from mutant phenotype
15054094 RGD
involved in type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
24157940 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10612420 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

menin

  • multiple endocrine neoplasia 1

  • multiple endocrine neoplasia I

  • multiple endocrine neoplasia type I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151595 Menin-MLL inhibitor-22 Inhibitor 99.85% Unkown
HY-103304 SB 268262 99.9% Unkown
HY-168182 Menin-MLL inhibitor 34 Inhibitor / Unkown
HY-RS08333 MEN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177140 CDD-1147 Inhibitor / Unkown
HY-RS18140 Men1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24615 Men1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Men1 NCBI NCBI:4221