Slc1a3 - solute carrier family 1 member 3 Gene

Also Known as EAAT1; GLAST; GluT-1; GLAST-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29483

Summary

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and malate-aspartate shuttle. Acts upstream of or within L-glutamate transmembrane transport and response to inorganic substance. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and neuronal cell body. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a3 Products (4)

mRNA Protein Name
NM_001289941.1 NP_001276870.1 excitatory amino acid transporter 1 isoform 2
NM_001289942.1 NP_001276871.1 excitatory amino acid transporter 1 isoform 3
NM_001289943.1 NP_001276872.1 excitatory amino acid transporter 1 isoform 4
NM_019225.2 NP_062098.1 excitatory amino acid transporter 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate transmembrane transporter activity IDA
IDA: Inferred from direct assay
15242733 RGD
enables glutamate:sodium symporter activity IMP
IMP: Inferred from mutant phenotype
1279699 RGD
enables high-affinity L-glutamate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
1279699 RGD
Biological Process GO Annotation Evidence References Source
involved in L-aspartate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
1279699 RGD
involved in L-glutamate import across plasma membrane IMP
IMP: Inferred from mutant phenotype
1279699 RGD
acts upstream of or within L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
7723632 RGD
involved in L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
15242733 RGD
involved in L-glutamate transmembrane transport IMP
IMP: Inferred from mutant phenotype
10899959 RGD
involved in malate-aspartate shuttle IDA
IDA: Inferred from direct assay
15242733 RGD
Cellular Component GO Annotation Evidence References Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
26133720 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
9219972 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
11950769 RGD
part of membrane protein complex IDA
IDA: Inferred from direct assay
9334410 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
15242733 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
26133720 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
26133720 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
1279699 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

excitatory amino acid transporter 1

  • glial glutamate transporter

  • glutamate transporter

  • glutamate/aspartate transporter

  • sodium-dependent glutamate/aspartate transporter 1

  • solute carrier family 1 (glial high affinity glutamate transporter), member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13054 SLC1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19528 Slc1a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26023 Slc1a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc1a3 NCBI NCBI:6507