Prps1 - phosphoribosyl pyrophosphate synthetase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29562

Summary

Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prps1 Products (1)

mRNA Protein Name
NM_017243.2 NP_058939.1 ribose-phosphate pyrophosphokinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables AMP binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables GDP binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables carbohydrate binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
1651917 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9366267 RGD
enables ribose phosphate diphosphokinase activity IDA
IDA: Inferred from direct assay
1651917 RGD
Biological Process GO Annotation Evidence References Source
involved in 5-phosphoribose 1-diphosphate biosynthetic process IDA
IDA: Inferred from direct assay
9366267 RGD
involved in AMP biosynthetic process IDA
IDA: Inferred from direct assay
2546925 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
2822704 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
2546925 RGD
part of ribose phosphate diphosphokinase complex IDA
IDA: Inferred from direct assay
2546925 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribose-phosphate pyrophosphokinase 1

  • PRS-I

  • phosphoribosyl pyrophosphate synthase I

  • phosphoribosyl pyrophosphate synthetase I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11219 PRPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128345 UDM-001651 Antagonist / Unkown
HY-RS18677 Prps1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25163 Prps1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prps1 NCBI NCBI:5631