Fdft1 - farnesyl diphosphate farnesyl transferase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29580

Summary

Enables farnesyl-diphosphate farnesyltransferase activity. Involved in Cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Located in endoplasmic reticulum membrane. Used to study cataract. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Fdft1 Products (1)

mRNA Protein Name
NM_019238.2 NP_062111.1 squalene synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables squalene synthase [NAD(P)H] activity IDA
IDA: Inferred from direct assay
1400448 RGD
enables squalene synthase [NAD(P)H] activity IMP
IMP: Inferred from mutant phenotype
16440058 RGD
Biological Process GO Annotation Evidence References Source
involved in cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
16440058 RGD
involved in farnesyl diphosphate metabolic process IMP
IMP: Inferred from mutant phenotype
16440058 RGD
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
8509416 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

squalene synthase

  • FPP:FPP farnesyltransferase

  • SQS

  • SS

  • farnesyl diphosphate farnesyltransferase

  • squalene synthetase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100313A YM-53601 Inhibitor 99.37% Unkown
HY-100313 YM-53601 free base Inhibitor / Unkown
HY-RS04852 FDFT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16915 Fdft1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23357 Fdft1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fdft1 NCBI NCBI:2222