Ptpn5 - protein tyrosine phosphatase, non-receptor type 5 Gene

Also Known as STEP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29644

Summary

Enables several functions, including identical protein binding activity; mitogen-activated protein kinase binding activity; and protein tyrosine Phosphatase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of intracellular protein transport; and regulation of protein phosphorylation. Located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Used to study transient cerebral ischemia. Biomarker of transient cerebral ischemia. Orthologous to human PTPN5 (protein tyrosine Phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn5 Products (1)

mRNA Protein Name
NM_001398605.1 NP_001385534.1 tyrosine-protein phosphatase non-receptor type 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27103516 RGD
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
19625523 RGD
Biological Process GO Annotation Evidence References Source
involved in exploration behavior IDA
IDA: Inferred from direct assay
17008368 RGD
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
9857190 RGD
involved in peptidyl-tyrosine dephosphorylation IDA
IDA: Inferred from direct assay
9857190 RGD
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
19026408 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
10101226 RGD
involved in positive regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
12483215 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19625523 RGD
involved in positive regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
19625523 RGD
involved in positive regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
19625523 RGD
involved in positive regulation of response to drug IMP
IMP: Inferred from mutant phenotype
19026408 RGD
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19625523 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
23711322 RGD
involved in response to immobilization stress IDA
IDA: Inferred from direct assay
17008368 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17623046 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
7869116 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8331384 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
10101226 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
8331384 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
27103516 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
27103516 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein phosphatase non-receptor type 5

  • neural-specific protein-tyrosine phosphatase

  • protein-tyrosine phosphatase striatum-enriched

  • protein-tyrosine-phosphatase non-receptor 5

  • striatum-enriched protein-tyrosine phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-141800 MurA-IN-1 Inhibitor 99.32% Unkown
HY-155847 LYP-IN-3 99.80% Unkown
HY-RS11428 PTPN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20091 Ptpn5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26594 Ptpn5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptpn5 NCBI NCBI:84867