P2RX7 - purinergic receptor P2X 7 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29665

About P2RX7

Primary_assembly 12: 33,879,745-33,934,619 reverse strand.mRatBN7.2:CM026985.1

This gene has 6 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 9 phenotypes. Biased expression in Liver (RPKM 74.), Lung (RPKM 67.2) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and metal ion binding activity. Involved in several processes, including ATP export; bleb assembly; and positive regulation of macromolecule metabolic process. Located in several cellular components, including bleb; membrane raft; and terminal bouton. Is integral component of nuclear inner membrane. Part of protein-containing complex. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2RX7 Products (1)

mRNA Protein Name
NM_019256.2 NP_062129.1 P2X purinoceptor 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
17394459 RGD
enables channel activity IDA
IDA: Inferred from direct assay
18519738 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
17394459 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
8614837 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
18938136 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17394459 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17036048 RGD
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
15023862 RGD
enables purinergic nucleotide receptor activity IDA
IDA: Inferred from direct assay
8614837 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
19416975 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
17785580 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
17394459 RGD
Biological Process GO Annotation Evidence References Source
involved in ATP export IMP
IMP: Inferred from mutant phenotype
31630543 RGD
involved in apoptotic signaling pathway IDA
IDA: Inferred from direct assay
12857854 RGD
involved in bleb assembly IDA
IDA: Inferred from direct assay
12857854 RGD
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12857854 RGD
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
8614837 RGD
involved in membrane depolarization IDA
IDA: Inferred from direct assay
8614837 RGD
involved in neuronal action potential IDA
IDA: Inferred from direct assay
17394459 RGD
involved in pore complex assembly IDA
IDA: Inferred from direct assay
15883745 RGD
involved in pore complex assembly IMP
IMP: Inferred from mutant phenotype
15883745 RGD
involved in positive regulation of cytoskeleton organization IDA
IDA: Inferred from direct assay
12857854 RGD
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
15883745 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
15883745 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15023862 RGD
involved in regulation of presynaptic dense core granule exocytosis EXP
EXP: Inferred from Experiment
24037803 RGD
involved in regulation of presynaptic dense core granule exocytosis IDA
IDA: Inferred from direct assay
24037803 RGD
involved in regulation of sodium ion transport IDA
IDA: Inferred from direct assay
17785580 RGD
involved in response to ATP IDA
IDA: Inferred from direct assay
8614837 RGD
Cellular Component GO Annotation Evidence References Source
located in bleb IDA
IDA: Inferred from direct assay
12857854 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
12857854 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
12422208 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
12857854 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19416975 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
16018975 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX7 Protein Structure

P2X_receptor

P2X_receptor: pfam00864 (10 - 412)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 7

  • ATP receptor

  • P2X purinoceptor 7-like

  • P2X7 purinoceptor

  • P2Z receptor

  • purinergic receptor P2X, ligand-gated ion channel, 7

  • purinergic receptor P2X7

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0298 Clemastine 99.26% Yes

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09912 P2rx7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09911 P2RX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09913 P2RX7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2RX7 NCBI NCBI:5027