Htra2 - HtrA serine peptidase 2 Gene

Also Known as Prss25

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 297376

Summary

Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to Herbicide. Located in cytosol and mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Htra2 Products (1)

mRNA Protein Name
NM_001106599.2 NP_001100069.1 serine protease HTRA2, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables serine-type peptidase activity IMP
IMP: Inferred from mutant phenotype
16978742 RGD
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IEP
IEP: Inferred from expression pattern
22296759 RGD
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18662332 RGD
involved in pentacyclic triterpenoid metabolic process IEP
IEP: Inferred from expression pattern
22296759 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16978742 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
22245251 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease HTRA2, mitochondrial

  • high temperature requirement protein A2

  • protease, serine, 25

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125959 Ucf-101 Inhibitor 99.65% Unkown
HY-RS06487 HTRA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20958 Htra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27475 Htra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htra2 NCBI NCBI:27429