Arid1a - AT-rich interaction domain 1A Gene

Predicted to enable ATP-dependent chromatin remodeler activity; DNA binding activity; and nuclear receptor binding activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in intracellular steroid hormone receptor signaling pathway; nucleosome disassembly; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including animal organ development; embryonic morphogenesis; and toxin transport. Predicted to be located in chromatin. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 2; breast cancer; carcinoma (multiple); gastrointestinal system Cancer (multiple); and neuroblastoma. Orthologous to human ARID1A (AT-rich interaction domain 1A). [provided by Alliance of Genome Resources, Apr 2022]