Sdhb - succinate dehydrogenase complex iron sulfur subunit B Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298596

Summary

Enables Succinate Dehydrogenase (ubiquinone) activity. Involved in respiratory electron transport chain and succinate metabolic process. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (Succinate Dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Sdhb Products (1)

mRNA Protein Name
NM_001100539.1 NP_001094009.1 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables succinate dehydrogenase (quinone) activity IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Biological Process GO Annotation Evidence References Source
involved in respiratory electron transport chain IMP
IMP: Inferred from mutant phenotype
16520240 RGD
involved in succinate metabolic process IMP
IMP: Inferred from mutant phenotype
16520240 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16520240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

  • ip

  • iron-sulfur subunit of complex II

  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12593 SDHB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169281 Antiviral agent 61 Inhibitor / Unkown
HY-RS18259 Sdhb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24738 Sdhb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sdhb NCBI NCBI:6390