LMCD1 - LIM and cysteine rich domains 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29995

About LMCD1

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:8,501,823-8,574,668 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in lung (RPKM 21.9), fat (RPKM 21.1) and 24 other tissues.

Summary

This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with Other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

LMCD1 Products (4)

mRNA Protein Name
NM_001278233.2 NP_001265162.1 LIM and cysteine-rich domains protein 1 isoform 2
NM_001278234.2 NP_001265163.1 LIM and cysteine-rich domains protein 1 isoform 3
NM_001278235.2 NP_001265164.1 LIM and cysteine-rich domains protein 1 isoform 4
NM_014583.4 NP_055398.1 LIM and cysteine-rich domains protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
20026769 GOA
involved in regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
20026769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMCD1 Protein Structure

PET

PET: PET Domain (98 - 202)

LIM

LIM: LIM domain (262 - 302)

LIM

LIM: LIM domain (308 - 360)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

LIM and cysteine-rich domains protein 1

  • dyxin

Recombinant LMCD1 Proteins

Cat. No. Product Name Accession Purity
HY-P70926 LMCD1 Protein, Human (His) Q9NZU5-1 (M1-S365) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lidocaine Allergy

  • Lidoderm Allergy

  • Lignocaine Allergy

  • Xylocaine Allergy
Mixed Cell Uveal Melanoma

  • Intraocular Mixed Cell Type Melanoma

  • Mixed Cell Type Uveal Melanoma
Posterior Uveal Melanoma

  • Medium/Large Size Posterior Uveal Melanoma

  • Small Size Posterior Uveal Melanoma

  • Ciliary Body And Choroid Melanoma, Medium/Large Size

  • Ciliary Body And Choroid Melanoma, Small Size
Orthostatic Intolerance

  • Mitral Valve Prolapse

  • Neurocirculatory Asthenia

  • Mitral Valve Prolapse Syndrome

  • Irritable Heart

  • Systolic Click-Murmur Syndrome

  • Soldiers Heart

  • Cardiovascular Malfunction Arising From Mental Factors

  • Cardiovascular Neurosis

  • Da Costa'S Syndrome

  • Krishaber'S Disease

  • Barlow'S Syndrome

  • Floppy Mitral Valve

  • Mitral Leaflet Syndrome

  • Myxomatous Mitral Valve Prolapse

  • Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency

  • Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

  • Orthostatic Intolerance Due To Net Deficiency

  • Pots Due To Net Deficiency

  • OI

  • Intolerance, Orthostatic

  • Mitral Valve Prolapse, Familial, X-Linked

  • Ballooning Mitral Valve

  • Barlow Syndrome

  • Flail Mitral Leaflet

  • Myxomatous Mitral Valve

  • Mitral Valve Prolapse-Click Syndrome

  • Prolapsing Mitral Valve Leaflet Syndrome

  • Billowing Mitral Valve Leaflet

  • Posterior Mitral Leaflet Deformity

  • Ballooning Posterior Leaflet Syndrome

  • Blue Valve Syndrome

  • Floppy Mitral Valve Syndrome

  • Mitral Valvular Prolapse

  • Systolic Click Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07710 LMCD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19705 Lmcd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26201 Lmcd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LMCD1 VGNC VGNC:42714
Bos taurus LMCD1 VGNC VGNC:30926
Felis catus LMCD1 VGNC VGNC:68065
Macaca mulatta LMCD1 VGNC VGNC:74426
Rattus norvegicus LMCD1 RGD RGD:1308963
Mus musculus LMCD1 MGD MGI:1353635
Others LMCD1 NCBI