Amot - angiomotin Gene

Also Known as RGD1564027

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300289

Summary

Predicted to enable angiostatin binding activity and signaling receptor activity. Predicted to be involved in several processes, including establishment of cell polarity involved in ameboidal cell migration; hippo signaling; and positive regulation of blood vessel endothelial cell migration. Predicted to act upstream of or within several processes, including gastrulation; negative regulation of GTPase activity; and vasculogenesis. Predicted to be located in several cellular components, including actin cytoskeleton; external side of plasma membrane; and ruffle. Predicted to be integral component of membrane. Predicted to be part of COP9 signalosome. Predicted to be active in several cellular components, including bicellular tight junction; cytoplasmic vesicle; and lamellipodium. Orthologous to human AMOT (angiomotin). [provided by Alliance of Genome Resources, Apr 2022]

Amot Products (6)

mRNA Protein Name
XM_006257423.4 XP_006257485.2 angiomotin isoform X1
XM_006257420.4 XP_006257482.2 angiomotin isoform X1
XM_006257422.2 XP_006257484.2 angiomotin isoform X1
XM_006257421.2 XP_006257483.2 angiomotin isoform X1
XM_006257424.4 XP_006257486.2 angiomotin isoform X2
XM_039100625.1 XP_038956553.1 angiomotin isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21481793 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
29317530 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
29317530 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29317530 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
29317530 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
29317530 RGD
is active in postsynaptic density IMP
IMP: Inferred from mutant phenotype
29317530 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiomotin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00663 AMOT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20691 Amot Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27202 Amot Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amot NCBI NCBI:154796