Opn4 - opsin 4 (melanopsin) Gene

Also Known as Gm533; 1110007J02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30044

Summary

Enables G protein-coupled photoreceptor activity. Involved in several processes, including hyaloid vascular plexus regression; optokinetic behavior; and phototransduction. Acts upstream of or within several processes, including detection of temperature stimulus involved in thermoception; entrainment of circadian clock by photoperiod; and thermotaxis. Located in sperm head plasma membrane. Is expressed in eye and future brain. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Apr 2022]

Opn4 Products (4)

mRNA Protein Name
NM_001128599.1 NP_001122071.1 melanopsin isoform 2
NM_013887.2 NP_038915.1 melanopsin isoform 1
NM_001128599.1 NP_001122071.1 melanopsin isoform 2
NM_013887.2 NP_038915.1 melanopsin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled photoreceptor activity IMP
IMP: Inferred from mutant phenotype
12808468 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within detection of temperature stimulus involved in thermoception IGI
IGI: Inferred from genetic interaction
31924821 MGI
involved in hyaloid vascular plexus regression IMP
IMP: Inferred from mutant phenotype
30936473 MGI
involved in optokinetic behavior IMP
IMP: Inferred from mutant phenotype
26392540 MGI
involved in phototransduction IMP
IMP: Inferred from mutant phenotype
12808468 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
12808468 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
21124780 MGI
acts upstream of or within thermotaxis IGI
IGI: Inferred from genetic interaction
31924821 MGI
Cellular Component GO Annotation Evidence References Source
located in sperm head plasma membrane IDA
IDA: Inferred from direct assay
31924821 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

melanopsin

  • opsin-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125145 AA92593 Antagonist 99.94% Unkown
HY-124157 AA41612 Antagonist 99.78% Unkown
HY-164428 AE 51310 Inhibitor / Unkown
HY-RS09799 OPN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20787 Opn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27301 Opn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Opn4 NCBI NCBI:94233
Rattus norvegicus Opn4 NCBI NCBI:192223