Spdef - SAM pointed domain containing ets transcription factor Gene

Also Known as Pse; PDEF

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30051

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell differentiation; positive regulation of cell fate commitment; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPDEF (SAM pointed domain containing ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Spdef Products (4)

mRNA Protein Name
NM_001357728.1 NP_001344657.1 SAM pointed domain-containing Ets transcription factor
NM_001414277.1 NP_001401206.1 SAM pointed domain-containing Ets transcription factor
NM_001414278.1 NP_001401207.1 SAM pointed domain-containing Ets transcription factor
NM_013891.4 NP_038919.1 SAM pointed domain-containing Ets transcription factor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of cell fate commitment IMP
IMP: Inferred from mutant phenotype
19759516 MGI
acts upstream of epithelial cell fate commitment IMP
IMP: Inferred from mutant phenotype
19759516 MGI
acts upstream of or within glandular epithelial cell development IMP
IMP: Inferred from mutant phenotype
19549527 MGI
acts upstream of or within intestinal epithelial cell development IMP
IMP: Inferred from mutant phenotype
19549527 MGI
acts upstream of or within lung goblet cell differentiation IDA
IDA: Inferred from direct assay
17347682 MGI
acts upstream of or within negative regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
19759516 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19759516 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19549527 MGI
acts upstream of or within positive regulation of cell fate commitment IMP
IMP: Inferred from mutant phenotype
19759516 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17347682 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17347682 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19549527 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19759516 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19759516 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19549527 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17347682 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SAM pointed domain-containing Ets transcription factor

  • prostate epithelium-specific Ets transcription factor

  • prostate specific ets transcription factor

  • prostate-derived Ets factor

  • prostate-specific Ets

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0603 Fluticasone Agonist 98.70% Yes

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13652 SPDEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17775 Spdef Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24242 Spdef Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spdef NCBI NCBI:25803