SPDEF - SAM pointed domain containing ETS transcription factor Gene

Also Known as PDEF; bA375E1.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25803

About SPDEF

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,537,802-34,556,329 (from NCBI)

This gene has 2 transcripts (splice variants), 245 orthologues and 28 paralogues. Biased expression in prostate (RPKM 50.1), salivary gland (RPKM 10.8) and 5 other tissues.

Summary

The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than Other cancer-associated molecules, making it a more suitable target for developing specific Cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SPDEF Products (2)

mRNA Protein Name
NM_001252294.2 NP_001239223.1 SAM pointed domain-containing Ets transcription factor isoform 2
NM_012391.3 NP_036523.1 SAM pointed domain-containing Ets transcription factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21656828 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21656828 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPDEF Protein Structure

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (132 - 212)

Ets

Ets: Ets-domain (249 - 333)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

SAM pointed domain-containing Ets transcription factor

  • prostate epithelium-specific Ets transcription factor

SPDEF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPDEF O95238 CEP57 Homo sapiens Q86XR8-3
Validated Y2H
32296183
Intra
SPDEF O95238 SNX20 Homo sapiens Q7Z614-3
Validated Y2H
32296183
Intra
SPDEF O95238 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra
SPDEF O95238 COX5A Homo sapiens P20674
Validated Y2H
32296183
Intra
SPDEF O95238 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra
SPDEF O95238 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
SPDEF O95238 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Allergic Cutaneous Vasculitis

  • Allergic Cutaneous Angiitis

  • Autoimmune Hypersensitivity Angiitis

  • Vasculitis, Leukocytoclastic, Cutaneous
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Ascending Colon Cancer

  • Malignant Tumor Of Ascending Colon

  • Ca Ascending Colon

  • Malignant Neoplasm Of Right Colon

  • Malignant Neoplasm Of Ascending Colon
Lung Mucoepidermoid Carcinoma

  • Mucoepidermoid Carcinoma Of Lung
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Potocki-Shaffer Syndrome

  • Proximal 11p Deletion Syndrome

  • Chromosome 11p11.2 Deletion Syndrome

  • Pss

  • 11p11.2 Deletion

  • P11pds

  • Defect11 Syndrome

  • Deletion Of Chromosome 11p11.2

  • POSHS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0603 Fluticasone Agonist 98.70% Yes

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13652 SPDEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17775 Spdef Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24242 Spdef Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPDEF VGNC VGNC:65628
Macaca mulatta SPDEF VGNC VGNC:104430
Canis familiaris SPDEF VGNC VGNC:46726
Rattus norvegicus SPDEF RGD RGD:1594842
Mus musculus SPDEF MGD MGI:1353422
Bos taurus SPDEF VGNC VGNC:35198
Others SPDEF NCBI