KCNIP1 - potassium voltage-gated channel interacting protein 1 Gene

Also Known as VABP; KCHIP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30820

About KCNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,353,487-170,736,632 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 14 paralogues. Biased expression in brain (RPKM 5.5), testis (RPKM 1.0) and 6 other tissues.

Summary

This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

KCNIP1 Products (5)

mRNA	Protein	Name
NM_001034837.3	NP_001030009.1	Kv channel-interacting protein 1 isoform 1
NM_001034838.3	NP_001030010.1	Kv channel-interacting protein 1 isoform 3
NM_001278339.2	NP_001265268.1	Kv channel-interacting protein 1 isoform 5
NM_001278340.2	NP_001265269.1	Kv channel-interacting protein 1 isoform 4
NM_014592.4	NP_055407.1	Kv channel-interacting protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	17187064	GOA
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	10676964	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10551270	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10676964	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Kv4.3-KChIP1 channel complex	IPI IPI: Inferred from physical interaction	17187064	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10676964	GOA
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	10676964	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	10676964	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP1 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
227 a.a.

Protein Preferred Names	Protein Names
Kv channel-interacting protein 1	A-type potassium channel modulatory protein 1

KCNIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNIP1	Q9NZI2	KCNIP2	Homo sapiens	Q9NS61-3	Pull Down	15358149
Intra	KCNIP1	Q9NZI2	KCND2	Homo sapiens	Q9NZV8	Pull Down	15358149
Intra	KCNIP1	Q9NZI2	KCND3	Homo sapiens	Q9UK17	X-Ray Diffraction	17187064

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epilepsy, Idiopathic Generalized	Idiopathic Generalized Epilepsy Generalised Epilepsy Epilepsy, Generalized EIG Ige Epilepsy, Idiopathic Generalized, Susceptibility To, 1 Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized, Susceptibility To Epilepsy, Idiopathic, Generalized Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Hypertension, Diastolic	Hypertension, Diastolic, Resistance To Diastolic Hypertension
Bacterial Pneumonia	Gram-Negative Pneumonia Pneumonia Due To Other Gram-Negative Bacteria Pneumonia Bacterial Pneumonia, Bacterial Acute Bacillus Pneumonia Acute Bacterial Pneumonia Bacillus Double Pneumonia Bacillus Pneumonia Bacteria Pneumonia Bacterial Double Pneumonia Bacterial Lobar Pneumonia Bacterial Purulent Pneumonia Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae
Acute Pyelonephritis	Apn - [Acute Pyelonephritis]
Pyelitis
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Urinary Tract Infection	Urinary Tract Infections Uti Urinary Tract Infection Nos Uti - [Urinary Tract Infection] Uti Nos - [Urinary Tract Infection Nos] Urosepsis Nos E Coli Uti E Coli Urinary Tract Infection Escherichia Coli Uti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07132	KCNIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNIP1	MGD	MGI:1917607
Canis familiaris	KCNIP1	VGNC	VGNC:42254
Felis catus	KCNIP1	VGNC	VGNC:63040
Rattus norvegicus	KCNIP1	RGD	RGD:70886
Macaca mulatta	KCNIP1	VGNC	VGNC:73832
Bos taurus	KCNIP1	VGNC	VGNC:30450
Others	KCNIP1	NCBI