KCNIP1 - potassium voltage-gated channel interacting protein 1 Gene

Homo sapiens

Also known as VABP; KCHIP1

Gene ID: 30820 | Gene type: protein coding

About KCNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,353,487-170,736,632 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 14 paralogues. Biased expression in brain (RPKM 5.5), testis (RPKM 1.0) and 6 other tissues.

Summary

This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

KCNIP1 Products(5)

mRNA	Protein	Name
NM_001034837.3	NP_001030009.1	Kv channel-interacting protein 1 isoform 1
NM_001034838.3	NP_001030010.1	Kv channel-interacting protein 1 isoform 3
NM_001278339.2	NP_001265268.1	Kv channel-interacting protein 1 isoform 5
NM_001278340.2	NP_001265269.1	Kv channel-interacting protein 1 isoform 4
NM_014592.4	NP_055407.1	Kv channel-interacting protein 1 isoform 2

KCNIP1 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
227 a.a.

Protein Preferred Names

Protein Names

Kv channel-interacting protein 1

A-type potassium channel modulatory protein 1

Related Diseases

Diseases

Alias

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Hypertension, Diastolic

Hypertension, Diastolic, Resistance To

Diastolic Hypertension

Bacterial Pneumonia

Gram-Negative Pneumonia	Pneumonia Due To Other Gram-Negative Bacteria
Pneumonia Bacterial	Pneumonia, Bacterial
Acute Bacillus Pneumonia	Acute Bacterial Pneumonia
Bacillus Double Pneumonia	Bacillus Pneumonia
Bacteria Pneumonia	Bacterial Double Pneumonia
Bacterial Lobar Pneumonia	Bacterial Purulent Pneumonia
Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Pyelitis

Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2	Pontocerebellar Hypoplasia Type 2e
Pch2	PCH2E
Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy	Pontocerebellar Hypoplasia 2e
Pcca2	Progressive Cerebello-Cerebral Atrophy Type 2
Doid:0112328	Hypoplasia, Pontocerebellar, Type 2e
Pontocerebellar Hypoplasia, Type 2d	Pontocerebellar Hypoplasia Type 2a

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07132	KCNIP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNIP1	MGD	MGI:1917607
Canis familiaris	KCNIP1	VGNC	VGNC:42254
Felis catus	KCNIP1	VGNC	VGNC:63040
Rattus norvegicus	KCNIP1	RGD	RGD:70886
Macaca mulatta	KCNIP1	VGNC	VGNC:73832
Bos taurus	KCNIP1	VGNC	VGNC:30450

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