Spint1 - serine peptidase inhibitor, Kunitz type 1 Gene

Also Known as HAI-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 311331

Summary

Enables serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus; negative regulation of neural precursor cell proliferation; and positive regulation of glial cell differentiation. Located in plasma membrane. Biomarker of liver cirrhosis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Apr 2022]

Spint1 Products (1)

mRNA Protein Name
NM_001004265.2 NP_001004265.2 kunitz-type protease inhibitor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
18048349 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to BMP stimulus IEP
IEP: Inferred from expression pattern
23409135 RGD
involved in negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
23409135 RGD
involved in positive regulation of glial cell differentiation IMP
IMP: Inferred from mutant phenotype
23409135 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kunitz-type protease inhibitor 1

  • hepatocyte growth factor activator inhibitor-1

  • serine protease inhibitor, Kunitz type 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13685 SPINT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18570 Spint1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25054 Spint1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spint1 NCBI NCBI:6692
Mus musculus Spint1 NCBI NCBI:20732