Adsl - adenylosuccinate lyase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315150

Summary

Enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; and identical protein binding activity. Involved in several processes, including AMP biosynthetic process; response to hypoxia; and response to muscle activity. Located in cytosol. Biomarker of breast Cancer. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]

Adsl Products (1)

mRNA Protein Name
NM_001130503.1 NP_001123975.1 adenylosuccinate lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IDA
IDA: Inferred from direct assay
3759987 RGD
enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IDA
IDA: Inferred from direct assay
3689310 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
3689310 RGD
Biological Process GO Annotation Evidence References Source
involved in AMP biosynthetic process IDA
IDA: Inferred from direct assay
3759987 RGD
involved in aerobic respiration IMP
IMP: Inferred from mutant phenotype
3777158 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
8887278 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
3777158 RGD
involved in response to nutrient IDA
IDA: Inferred from direct assay
7128902 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
690130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylosuccinate lyase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109056 Elsulfavirine Inhibitor 99.90% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109056A Elsulfavirine sodium Inhibitor / Unkown
HY-RS00418 ADSL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18123 Adsl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24597 Adsl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adsl NCBI NCBI:158