Manf - mesencephalic astrocyte-derived neurotrophic factor Gene

Also Known as Armet

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315989

Summary

Predicted to enable sulfatide binding activity. Predicted to be involved in dopaminergic neuron differentiation; neuron projection development; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Located in extracellular space and perinuclear region of cytoplasm. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic Cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Manf Products (1)

mRNA Protein Name
NM_001401064.1 NP_001387993.1 mesencephalic astrocyte-derived neurotrophic factor precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19641128 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19641128 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mesencephalic astrocyte-derived neurotrophic factor

  • arginine-rich protein

  • arginine-rich, mutated in early stage tumors

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08017 MANF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18040 Manf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24514 Manf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Manf NCBI NCBI:7873