HOXA4 - homeobox A4 Gene

Also Known as HOX1; HOX1D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3201

About HOXA4

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,128,525-27,130,757 (from NCBI)

This gene has 4 transcripts (splice variants), 188 orthologues and 42 paralogues. Broad expression in esophagus (RPKM 4.4), lung (RPKM 4.1) and 19 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

HOXA4 Products (1)

mRNA Protein Name
NM_002141.5 NP_002132.3 homeobox protein Hox-A4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA4 Protein Structure

Homeobox

Homeobox: Homeobox domain (216 - 272)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-A4

  • Dfd-like protein

Related Diseases

Diseases Alias
Athabaskan Brainstem Dysgenesis Syndrome

  • Bosley-Salih-Alorainy Syndrome

  • Navajo Brainstem Syndrome

  • ABDS

  • Human Hoxa1 Syndromes

  • BSAS

  • Athabaskan Brainstem Dysgenesis

  • Bosley Salih Alorainy Syndrome

  • Absd

  • Athabascan Brainstem Dysgenesis Syndrome

  • Narvajo Brainstem Syndrome
Hypospadias

  • Hypospadias Familial

  • Familial Hypospadias
Hand-Foot-Genital Syndrome

  • Hand-Foot-Uterus Syndrome

  • Hfgs

  • Hfg Syndrome

  • Hfu Syndrome

  • HFG

  • Hfu

  • Hand Foot Uterus Syndrome

  • Hand Foot Genital Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06299 HOXA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HOXA4 VGNC VGNC:41748
Mus musculus HOXA4 MGD MGI:96176
Bos taurus HOXA4 VGNC VGNC:29912
Felis catus HOXA4 VGNC VGNC:80596
Rattus norvegicus HOXA4 RGD RGD:2814
Macaca mulatta HOXA4 VGNC VGNC:81326
Others HOXA4 NCBI