Phf8 - PHD finger protein 8 Gene

Predicted to enable several functions, including Histone Demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; histone lysine demethylation; and regulation of gene expression. Predicted to act upstream of or within chromatin organization. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including brain; early conceptus; olfactory epithelium; ovary; and vibrissa follicle. Used to study syndromic X-linked intellectual disability Siderius type. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Siderius type. Orthologous to human PHF8 (PHD finger protein 8). [provided by Alliance of Genome Resources, Apr 2022]