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Chd7 - chromodomain helicase DNA binding protein 7 Gene

Also Known as Dz; Mt; Cyn; Edy; Flo; Lda; Obt; Whi; Cycn; Todo; WBE1; metis; GENA 47; GENA 60; Gena 52; A730019I05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 320790

Summary

This gene encodes a protein containing two chromodomains and an ATP-binding helicase domain that functions as a regulator of transcription. Mutations in this gene result in an array of development defects, including inner ear problems. Mice defective for this gene exhibit many of the clinical features of the CHARGE syndrome caused by mutations in the homologous gene in human. [provided by RefSeq, Sep 2015]

Chd7 Products (2)

mRNA	Protein	Name
NM_001277149.1	NP_001264078.1	chromodomain-helicase-DNA-binding protein 7 isoform 1
NM_001355382.1	NP_001342311.1	chromodomain-helicase-DNA-binding protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23319608	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	26102480	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21532573	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult heart development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within artery morphogenesis	IGI IGI: Inferred from genetic interaction	19855134	MGI
acts upstream of or within atrioventricular canal development	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within blood circulation	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10932191	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within epithelium development	IMP IMP: Inferred from mutant phenotype	19279158	MGI
acts upstream of or within female genitalia development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15353999	MGI
acts upstream of or within innervation	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	10932191	MGI
acts upstream of or within nose development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within olfactory behavior	IMP IMP: Inferred from mutant phenotype	19279158	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	19279158	MGI
acts upstream of or within olfactory nerve development	IMP IMP: Inferred from mutant phenotype	19279158	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19279158	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
acts upstream of or within right ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	16207732	MGI
acts upstream of or within semicircular canal morphogenesis	IGI IGI: Inferred from genetic interaction	19855134	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	10932191	MGI
acts upstream of or within tissue remodeling	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26102480	MGI
acts upstream of or within ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	26102480	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	26102480	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
chromodomain-helicase-DNA-binding protein 7	ATP-dependent helicase CHD7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21310	Chd3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-111303	CHIC35	Inhibitor	/	Unkown
HY-RS02612	CHD7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17534	Chd7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23991	Chd7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chd7	NCBI	NCBI:55636