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ERAS - ES cell expressed Ras Gene

Also Known as HRAS2; HRASP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3266

About ERAS

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,826,513-48,829,869 (from NCBI)

This gene has 2 transcripts (splice variants), 72 orthologues and 35 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in Cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]

ERAS Products (1)

mRNA	Protein	Name
NM_181532.3	NP_853510.1	GTPase ERas precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERAS Protein Structure

Ras

0
100
200
233 a.a.

Protein Preferred Names	Protein Names
GTPase ERas	E-Ras

Related Diseases

Diseases	Alias
Immunodeficiency 54	Natural Killer Cell Deficiency, Familial Isolated Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency IMD54 Nkcd Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect Nkgcd Familial Isolated Natural Killer Cell Deficiency Primary Immunodeficiency Due To Mcm4 Deficiency
Loose Anagen Hair Syndrome	Loose Anagen Syndrome LAHS
Posterior Pituitary Gland Neoplasm	Posterior Pituitary Tumor Neoplasm Of The Posterior Pituitary
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Eccrine Papillary Adenocarcinoma	Digital Papillary Adenocarcinoma Sweat Gland Adenocarcinoma Digital Papillary Eccrine Carcinoma Of Skin
Apocrine Adenoma	Tubular Apocrine Adenoma
Eccrine Adenocarcinoma
Anorectal Stricture	Stenosis Of Rectum And Anus Anorectal Malformations
Syringocystadenoma Papilliferum	Fistulous Vegetative Verrucous Hydradenoma Papillary Syringadenoma Naevus Syringocystadenomatosus Papilliferus Papillary Syringocystadenoma Scap Syringadenoma Papilliferum Papillary Hidradenoma
Spleen Angiosarcoma	Angiosarcoma Of Spleen Splenic Hemangiosarcoma
Noonan Syndrome-Like Disorder With Loose Anagen Hair	Noonan-Like Syndrome With Loose Anagen Hair Mazzanti Syndrome Ns/Lah
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Familial Isolated Trichomegaly	Long Eyelashes Tcmgly
Mongolian Spot	Mongolian Macula
Brain Compression	Compression Of Brain
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Schimmelpenning-Feuerstein-Mims Syndrome	Nevus Sebaceus Of Jadassohn Organoid Nevus Phakomatosis Linear Nevus Sebaceous Syndrome Sfm Syndrome Jadassohn Nevus Phakomatosis Jnp Schimmelpenning Syndrome Solomon Syndrome SFM Linear Sebaceous Nevus Syndrome Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic Nevus Sebaceus Syndrome Organoid Nevus Syndrome Schimmelpenning Feuerstein Mims Syndrome Sebaceous Nevus Syndrome, Linear Epidermal Nevus Syndrome, Formerly Sebaceous Nevus Syndrome Linear Linear Nevus Sebaceus Syndrome Epidermal Nevus Syndrome Ss Nevus Sebaceous
Cardiofaciocutaneous Syndrome 1	Cardiofaciocutaneous Syndrome Cfc Syndrome Cardio-Facio-Cutaneous Syndrome CFC1 Cfcs Cardio-Facial-Cutaneous Syndrome Congenital Heart Defects Characteristic Facial Appearance Ectodermal Abnormalities And Growth Failure Cardiofaciocutaneous Syndrome, Type 1
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175870	Eras-4001	Inhibitor	98.27%	Unkown
HY-W654077	Bisphenol AF-d4		99.95%	Unkown
HY-175870A	(7R)-Eras-4001	Inhibitor	/	Unkown
HY-RS04465	ERAS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W727814	Pipendoxifene-d10		/	Unkown
HY-168644	Erα-IN-1	Inhibitor	/	Unkown
HY-174717	Human ERAS mRNA		/	Unkown
HY-49537	ER ligand-10	Ligand	/	Unkown
HY-RS17053	Eras Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23497	Eras Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99856	Docaravimab	Inhibitor	99.27%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ERAS	RGD	RGD:1585907
Bos taurus	ERAS	VGNC	VGNC:28562
Mus musculus	ERAS	MGD	MGI:2665023
Macaca mulatta	ERAS	VGNC	VGNC:72256
Canis familiaris	ERAS	VGNC	VGNC:40435
Others	ERAS	NCBI