HRH2 - histamine receptor H2 Gene

Also Known as H2R; HH2R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3274

About HRH2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,658,071-175,710,756 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 25 paralogues. Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues.

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine Receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

HRH2 Products (9)

mRNA	Protein	Name
NR_171689.1
NR_160284.1
XM_006714865.4	XP_006714928.1	histamine H2 receptor isoform X2
NM_022304.2
NM_001393461.1	NP_001380390.1	histamine H2 receptor isoform 1
NM_001131055.2	NP_001124527.1	histamine H2 receptor isoform 1
NM_001367711.1	NP_001354640.1	histamine H2 receptor isoform 2
NM_001393460.1	NP_001380389.1	histamine H2 receptor isoform 1
XM_011534549.4	XP_011532851.1	histamine H2 receptor isoform X1

HRH2 Protein Structure

7tm_1

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
histamine H2 receptor	gastric receptor 1 gastric receptor I

Related Diseases

Diseases	Alias
Peptic Esophagitis	Reflux Esophagitis Peptic Reflux Disease Reflux Oesophagitis Esophagitis, Peptic Gastro-Esophageal Reflux Disease With Esophagitis
Laryngitis	Acute Laryngitis
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Duodenogastric Reflux
Chronic Laryngitis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Duodenal Gastrinoma	Duodenal G-Cell Gastrin Producing Tumor Gastrinoma Of Duodenum Malignant Duodenal Gastrinoma Duodenal Gastrin-Producing Neuroendocrine Tumor
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Pancreatic Gastrinoma	Pancreatic G-Cell Tumor
Aspiration Pneumonitis	Chemical Pneumonitis Mendelson'S Syndrome Aspiration Pneumonia Pneumonitis Due To Fumes And/Or Vapors Toxic Pneumonitis Mendelson'S Syndrome Resulting From A Procedure Mendelson Syndrome Resulting From A Procedure Pulmonary Acid Aspiration Syndrome Pneumonitis Due To Inhalation Of Gastric Secretions Mendelson Syndrome Due To Anaesthesia During Labour And Delivery Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery
Necrotizing Gastritis
Zollinger-Ellison Syndrome	Gastrinoma Pancreatic Ulcerogenic Tumor Syndrome Z E Syndrome Zes Ze - [Zollinger-Ellison] Syndrome
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Hernia, Hiatus	Hiatal Hernia Hiatus Hernia Diaphragmatic - Hiatus -Hernia Hernia, Hiatal
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Cascade Stomach	Hourglass Stricture Or Stenosis Of Stomach Hourglass Contraction Of Stomach Hourglass Stenosis Of Stomach Hourglass Stricture Of Stomach
Internal Hordeolum
Bacterial Gastritis
Peptic Ulcer Disease	Peptic Ulcer Acute Peptic Ulcer With Hemorrhage Acute Peptic Ulcer With Hemorrhage And Perforation Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Dyskinesia Of Esophagus	Esophageal Motility Disorders Dyskinesia Of Oesophagus Esophageal Dysmotility Esophageal Motility Disorder Oesophageal Dysmotility Oesophageal Motor Disorder Esophageal Spasm
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Stomach Disease	Gastropathy Stomach Diseases Gastric Disease Stomach Disorder Gastric Disorder Stomach Disorders
Urticaria	Nettle Rash Hives Wheal Urticaria Nos
Peptic Ulcer Perforation	Perforated Peptic Ulcer Acute Peptic Ulcer With Perforation Peptic Ulcer With Perforation
Active Peptic Ulcer Disease	Gi Bleeding Active Peptic Ulcer Gastrointestinal Hemorrhage
Gastric Ulcer	Stomach Ulcer Acute Gastric Ulcer With Haemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction Acute Gastric Ulcer With Hemorrhage, With Obstruction Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction Acute Gastric Ulcer With Perforation Acute Gastric Ulcer With Perforation And Obstruction Acute Gastric Ulcer With Perforation, With Obstruction Acute Gastric Ulcer Without Hemorrhage And Without Perforation Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction Bleeding Acute Gastric Ulcer Chronic Gastric Ulcer Without Hemorrhage And Without Perforation Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction Gastric Ulcers Cushings Ulcer Cushing'S Ulcer Of Stomach Peptic Ulcer Of Stomach Mucosal Defect Of The Stomach
Pancreatic Cholera	Excessive Vasoactive Intestinal Peptide Secretion Pancreatic Wdha Syndrome Verner-Morrison Syndrome
Esophagitis	Acute Esophagitis
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-170442	ECI830	Inhibitor	98.01%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156959	Ovalicin	Inhibitor	/	Unkown
HY-RS06362	HRH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06363	Hrh2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06364	Hrh2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20393	Dhx15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HRH2	RGD	RGD:2831
Bos taurus	HRH2	VGNC	VGNC:29954
Felis catus	HRH2	VGNC	VGNC:67650
Mus musculus	HRH2	MGD	MGI:108482
Canis familiaris	HRH2	VGNC	VGNC:41787
Macaca mulatta	HRH2	VGNC	VGNC:73523
Others	HRH2	NCBI