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Card9 - caspase recruitment domain family, member 9 Gene

Also Known as Gm782

Species: Mus musculus

Gene Type: protein coding

Gene ID: 332579

Summary

Enables CARD domain binding activity. Involved in several processes, including Antifungal innate immune response; host-mediated regulation of intestinal microbiota composition; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of JNK cascade; regulation of cytokine production; and response to bacterium. Part of CBM complex. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human CARD9 (Caspase recruitment domain family member 9). [provided by Alliance of Genome Resources, Apr 2022]

Card9 Products (1)

mRNA	Protein	Name
NM_001037747.3	NP_001032836.1	caspase recruitment domain-containing protein 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	22265677	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17187069	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in antifungal innate immune response	IDA IDA: Inferred from direct assay	22265677	MGI
involved in antifungal innate immune response	IMP IMP: Inferred from mutant phenotype	24470469	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	23732773	MGI
involved in immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	33548172	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in neutrophil mediated immunity	IMP IMP: Inferred from mutant phenotype	25621893	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25267792	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	22265677	MGI
NOT acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	29080677	MGI
involved in positive regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	24470469	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	24470469	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	22265677	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	26679537	MGI
involved in positive regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	25267792	MGI
acts upstream of or within positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17187069	MGI
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	29080677	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	16862125	MGI
acts upstream of or within regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16862125	MGI
acts upstream of or within regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16862125	MGI
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within response to fungus	IMP IMP: Inferred from mutant phenotype	16862125	MGI
acts upstream of or within response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17187069	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17187069	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of CBM complex	IDA IDA: Inferred from direct assay	22265677	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
caspase recruitment domain-containing protein 9

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115497	BRD5529	Inhibitor	98.94%	Unkown
HY-RS01923	CARD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18055	Card9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24530	Card9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Card9	NCBI	NCBI:64170