IGKC - immunoglobulin kappa constant Gene

Also Known as Km; HCAK1; IGKCD

Species: Homo sapiens

Gene Type: other
Gene ID: 3514

About IGKC

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,857,361-88,857,683 (from NCBI)

This gene has 1 transcript (splice variant), 100 orthologues, 82 paralogues and is associated with 1 phenotype.

Summary

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in retina homeostasis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
involved in adaptive immune response IDA
IDA: Inferred from direct assay
11498595 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of IgG immunoglobulin complex IPI
IPI: Inferred from physical interaction
11498595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGKC Protein Structure

C1-set

C1-set: Immunoglobulin C1-set domain (12 - 98)

  • 0
  • 100
  • 107 a.a.

IGKC Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82251 Human kappa Light Chain Antibody (YA1996) WB, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Immunoglobulin Kappa Light Chain Deficiency

  • Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency

  • IGKCD

  • Kappa Chain Deficiency

  • Kappa Light Chain Deficiency

  • Kappa-Chain Deficiency

  • Igg Subclass Deficiency With Iga Subclass Deficiency

  • Isolated Igg Subclass Deficiency

  • Selective Igg Subclass Deficiency
Amyloidosis

  • Amyloid Disease

  • Amyloid

  • Amyloid Degeneration

  • Amyloidosis Nos

  • Amyloid Deposition

  • Amyloid Infiltration

  • Idiopathic Amyloidosis

  • Hyaloid Degeneration

  • Lardaceous Degeneration
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
Lymphoma, Mucosa-Associated Lymphoid Type

  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS19105 Igkc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25253 Igkc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IGKC RGD RGD:1562743