Slit2 - slit guidance ligand 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360272

Summary

Enables heparan sulfate proteoglycan binding activity. Involved in several processes, including central nervous system development; negative regulation of inflammatory response; and negative regulation of monocyte chemotaxis. Located in plasma membrane. Biomarker of anti-basement membrane glomerulonephritis. Orthologous to human SLIT2 (slit guidance ligand 2). [provided by Alliance of Genome Resources, Apr 2022]

Slit2 Products (1)

mRNA Protein Name
NM_022632.2 NP_072154.2 slit homolog 2 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
10364234 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15528323 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
26764532 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
21315131 RGD
involved in negative regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
15528323 RGD
involved in neuron projection extension IMP
IMP: Inferred from mutant phenotype
26738857 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
26738857 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
16497807 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
10102268 RGD
involved in synapse maturation IDA
IDA: Inferred from direct assay
34686348 RGD
involved in synapse maturation IMP
IMP: Inferred from mutant phenotype
34686348 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
26738857 RGD
located in cell body IDA
IDA: Inferred from direct assay
27686659 RGD
located in cell projection IDA
IDA: Inferred from direct assay
27686659 RGD
located in dendrite IDA
IDA: Inferred from direct assay
26738857 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
26738857 RGD
is active in perisynaptic extracellular matrix EXP
EXP: Inferred from Experiment
34686348 RGD
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
34686348 RGD
is active in perisynaptic extracellular matrix IMP
IMP: Inferred from mutant phenotype
34686348 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

slit homolog 2 protein

  • slit-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175200 DEL-S1 Ligand 98.50% Unkown
HY-146411 microRNA-21-IN-1 98.03% Unkown
HY-RS13371 SLIT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19035 Slit2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25524 Slit2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slit2 NCBI NCBI:9353