Pf4 - platelet factor 4 Gene

Also Known as PF-4; Pf4a; Cxcl4; RATPF4A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360918

Summary

Predicted to enable CXCR3 Chemokine Receptor binding activity; chemokine activity; and heparin binding activity. Involved in immune response and protein-containing complex assembly. Located in platelet alpha granule. Part of protein-containing complex. Orthologous to several human genes including PF4 (Platelet Factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Pf4 Products (1)

mRNA Protein Name
NM_001007729.2 NP_001007730.1 platelet factor 4 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in immune response IDA
IDA: Inferred from direct assay
12383857 RGD
involved in negative regulation of T-helper 17 cell differentiation IDA
IDA: Inferred from direct assay
24986443 RGD
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
24986443 RGD
involved in protein-containing complex assembly IPI
IPI: Inferred from physical interaction
12676928 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
Cellular Component GO Annotation Evidence References Source
located in platelet alpha granule IDA
IDA: Inferred from direct assay
2379543 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12676928 RGD
located in vesicle IDA
IDA: Inferred from direct assay
2379543 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet factor 4

  • C-X-C motif chemokine 4

  • chemokine (C-X-C motif) ligand 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17400 Pf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10355 PF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10356 PF4V1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23855 Pf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990391 Anti-CXCL4/PF4 Antibody 95.15% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pf4 NCBI NCBI:5196