PCK2 - Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) Gene

Also Known as PEPCK-M

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361042

Summary

Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and positive regulation of Insulin secretion. Located in mitochondrion. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

PCK2 Products (1)

mRNA Protein Name
NM_001108377.2 NP_001101847.2 phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphoenolpyruvate carboxykinase (GTP) activity IDA
IDA: Inferred from direct assay
6049928 RGD
enables phosphoenolpyruvate carboxykinase activity IDA
IDA: Inferred from direct assay
4353083 RGD
Biological Process GO Annotation Evidence References Source
involved in NADH oxidation IDA
IDA: Inferred from direct assay
19635791 RGD
involved in NADH oxidation IMP
IMP: Inferred from mutant phenotype
19635791 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19635791 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
19268478 RGD
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
4353083 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
6049928 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19635791 RGD
involved in pyruvate metabolic process IMP
IMP: Inferred from mutant phenotype
19635791 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
16570165 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19268478 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10153 PCK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16227 Pck2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23789 Pck2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PCK2 NCBI NCBI:5106