Top2b - DNA topoisomerase II beta Gene

生物種: Rattus norvegicus

遺伝子タイプ: protein coding
遺伝子ID: 361100

Summary

Enables ribonucleoprotein complex binding activity. Involved in several processes, including cellular response to ATP; cellular response to hydrogen peroxide; and positive regulation of double-strand break repair via nonhomologous end joining. Located in nucleolus. Orthologous to human TOP2B (DNA Topoisomerase II beta). [provided by Alliance of Genome Resources, Apr 2022]

Top2b Products (1)

mRNA Protein Name
NM_001100858.2 NP_001094328.2 DNA topoisomerase 2-beta

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables ribonucleoprotein complex binding IPI
IPI: Inferred from physical interaction
20554522 RGD
Biological Process GO Annotation Evidence 参考文献 由来
involved in cellular response to ATP IDA
IDA: Inferred from direct assay
25034690 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
22019940 RGD
involved in cellular senescence IEP
IEP: Inferred from expression pattern
20708677 RGD
involved in positive regulation of double-strand break repair via nonhomologous end joining IMP
IMP: Inferred from mutant phenotype
22019940 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA topoisomerase 2-beta

  • topoisomerase (DNA) II beta

  • topoisomerase II beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-174374 Topobexin Inhibitor 99.04% Unkown
HY-123393 PNU-142586 Inhibitor 97.92% Unkown
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175834 DNA/TOP2A-IN-1 / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-RS20119 Top2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26623 Top2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Top2b NCBI NCBI:7155