Ptges3 - prostaglandin E synthase 3 Gene

Also Known as RGD1561913

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362809

Summary

Enables several functions, including HSP90 protein binding activity; p53 binding activity; and prostaglandin-E synthase activity. Involved in several processes, including negative regulation of cell death; prostaglandin biosynthetic process; and sensory perception of pain. Located in several cellular components, including actin filament; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human PTGES3 (prostaglandin E synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

Ptges3 Products (1)

mRNA Protein Name
NM_001130989.2 NP_001124461.1 prostaglandin E synthase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
12684036 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
9488468 RGD
enables p53 binding IDA
IDA: Inferred from direct assay
9488468 RGD
enables prostaglandin-E synthase activity IDA
IDA: Inferred from direct assay
10922363 RGD
Biological Process GO Annotation Evidence References Source
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19145491 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21334450 RGD
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
10922363 RGD
involved in prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
10922363 RGD
involved in prostaglandin metabolic process IMP
IMP: Inferred from mutant phenotype
21334450 RGD
Cellular Component GO Annotation Evidence References Source
located in actin filament IDA
IDA: Inferred from direct assay
8864660 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20796173 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20796173 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
20796173 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin E synthase 3

  • cPGES

  • cytosolic prostaglandin E2 synthase

  • hsp90 co-chaperone

  • progesterone receptor complex p23

  • prostaglandin E synthase 3 (cytosolic)

  • telomerase-binding protein p23

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11381 PTGES3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19805 Ptges3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26301 Ptges3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptges3 NCBI NCBI:10728