Als2 - alsin Rho guanine nucleotide exchange factor ALS2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363235

Summary

Predicted to enable enzyme activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Involved in several processes, including Rac protein signal transduction; axonogenesis; and in utero embryonic development. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2). [provided by Alliance of Genome Resources, Apr 2022]

Als2 Products (1)

mRNA Protein Name
NM_001013413.1 NP_001013431.1 alsin

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in Rac protein signal transduction IDA
IDA: Inferred from direct assay
16802292 RGD
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
16802292 RGD
involved in in utero embryonic development IEP
IEP: Inferred from expression pattern
16049005 RGD
involved in regulation of endosome size IMP
IMP: Inferred from mutant phenotype
16802292 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15033976 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
15033976 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15033976 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16049005 RGD
located in membrane IDA
IDA: Inferred from direct assay
15033976 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15033976 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alsin

  • ALS2, alsin Rho guanine nucleotide exchange factor

  • amyotrophic lateral sclerosis 2 (juvenile)

  • amyotrophic lateral sclerosis 2 protein homolog

  • amyotrophic lateral sclerosis protein 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W611371A FP802 dihydrochloride Inhibitor 99.84% Unkown
HY-RS00634 ALS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00635 ALS2CL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17942 Als2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24413 Als2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Als2 NCBI NCBI:57679