Usp9x - ubiquitin specific peptidase 9, X-linked Gene

Predicted to enable co-SMAD binding activity; cysteine-type peptidase activity; and ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including positive regulation of DNA demethylation; protein deubiquitination involved in ubiquitin-dependent protein catabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; in utero embryonic development; and nervous system development. Predicted to be located in apical part of cell; cytoplasm; and growth cone. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in female-restricted syndromic X-linked intellectual disability 99 and non-syndromic X-linked intellectual disability 99. Orthologous to human USP9X (ubiquitin specific peptidase 9 X-linked). [provided by Alliance of Genome Resources, Apr 2022]