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Ntsr1 - neurotensin receptor 1 Gene

Also Known as Ntsr

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 366274

About Ntsr1

Primary_assembly 3: 167,606,215-167,656,377 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 213 orthologues, 14 paralogues and is associated with 10 phenotypes. Biased expression in Brain (RPKM 6.6), Muscle (RPKM 3.2) and 7 other tissues.

Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including amino acid import across plasma membrane; regulation of ion transport; and regulation of nervous system process. Located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human NTSR1 (Neurotensin Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntsr1 Products (1)

mRNA	Protein	Name
NM_001108967.2	NP_001102437.1	neurotensin receptor type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17188644	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16708210	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17188644	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in D-aspartate import across plasma membrane	IDA IDA: Inferred from direct assay	12123836	RGD
involved in L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	12123836	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	15733655	RGD
involved in inositol phosphate catabolic process	IMP IMP: Inferred from mutant phenotype	15707678	RGD
involved in learning	IMP IMP: Inferred from mutant phenotype	21946307	RGD
involved in negative regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	12084713	RGD
involved in negative regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	22211865	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18063561	RGD
involved in positive regulation of arachidonate secretion	IMP IMP: Inferred from mutant phenotype	11852105	RGD
involved in positive regulation of cation channel activity	IMP IMP: Inferred from mutant phenotype	19359367	RGD
involved in positive regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	15716398	RGD
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	18063561	RGD
involved in positive regulation of inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15664687	RGD
involved in positive regulation of inositol phosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	11861328	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	10799761	RGD
involved in regulation of membrane depolarization	IMP IMP: Inferred from mutant phenotype	15120846	RGD
involved in regulation of respiratory gaseous exchange	IMP IMP: Inferred from mutant phenotype	22211865	RGD
involved in response to lipid	IDA IDA: Inferred from direct assay	22306739	RGD
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	7620825	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	8876464	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	8876464	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17188644	RGD
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	9763490	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10818259	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	9763490	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	9763490	RGD
located in neuron spine	IDA IDA: Inferred from direct assay	10818259	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9763490	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10818259	RGD
located in symmetric synapse	IDA IDA: Inferred from direct assay	10818259	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	10818259	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntsr1 Protein Structure

7tmA_NTSR1

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
neurotensin receptor type 1	NT-R-1 NTR1 NTRH high-affinity levocabastine-insensitive neurotensin receptor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125880	SBI-553	Modulator	99.73%	Unkown
HY-164795A	SBI-810 hydrochloride		99.55%	Unkown
HY-164795	SBI-810		98.25%	Unkown
HY-RS09638	NTSR1 Human Pre-designed siRNA Set A		/	Unkown
HY-153709	Zalsenertant tetraxetan	Antagonist	/	Unkown
HY-182551	SR-12062	Agonist	/	Unkown
HY-P10698	VH-N412		/	Unkown
HY-P11845	DOTA-NT-20.3-IPBA	Modulator	/	Unkown
HY-RS09639	Ntsr1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09640	Ntsr1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntsr1	NCBI	NCBI:4923