Unc13a - unc-13 homolog A Gene

Also Known as Munc13-1; 2410078G03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 382018

Summary

Enables diacylglycerol binding activity. Involved in several processes, including positive regulation of glutamate receptor signaling pathway; positive regulation of synaptic plasticity; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including amyloid-beta metabolic process; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in calyx of Held and neuromuscular junction. Is active in glutamatergic synapse and presynaptic active zone. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Unc13a Products (1)

mRNA Protein Name
NM_001029873.2 NP_001025044.2 protein unc-13 homolog A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
31787876 MGI
enables diacylglycerol binding IDA
IDA: Inferred from direct assay
15123597 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10488064 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
15123597 MGI
NOT involved in dense core granule docking IGI
IGI: Inferred from genetic interaction
26575293 MGI
acts upstream of or within innervation IGI
IGI: Inferred from genetic interaction
15988013 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
15988013 MGI
involved in neuronal dense core vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
23229896 MGI
acts upstream of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
11792326 MGI
involved in positive regulation of glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23070049 MGI
acts upstream of or within positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
11792326 MGI
involved in positive regulation of synaptic plasticity IGI
IGI: Inferred from genetic interaction
23658173 MGI
involved in regulation of amyloid precursor protein catabolic process IMP
IMP: Inferred from mutant phenotype
23070049 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11832228 MGI
acts upstream of or within synaptic transmission, glutamatergic IGI
IGI: Inferred from genetic interaction
11792326 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
11832228 MGI
acts upstream of or within synaptic vesicle docking IGI
IGI: Inferred from genetic interaction
19558619 MGI
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
10440375 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
10440375 MGI
acts upstream of or within synaptic vesicle maturation IMP
IMP: Inferred from mutant phenotype
10440375 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
11832228 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23791195 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
23658173 MGI
located in calyx of Held IDA
IDA: Inferred from direct assay
23658173 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10440375 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10440375 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
15988013 MGI
located in presynapse IDA
IDA: Inferred from direct assay
25609709 MGI
is active in presynaptic active zone IDA
IDA: Inferred from direct assay
23658173 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
23658173 MGI
located in synapse IDA
IDA: Inferred from direct assay
23791195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein unc-13 homolog A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15464 UNC13A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21216 Unc13a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27732 Unc13a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Unc13a NCBI NCBI:23025