Zhx2 - zinc fingers and homeoboxes 2 Gene

Also Known as Raf; Afr1; Afr-1; mKIAA0854

Species: Mus musculus

Gene Type: protein coding
Gene ID: 387609

About Zhx2

Chromosome 15: 57,558,061-57,703,228 forward strand.GRCm39:CM001008.3

This gene has 2 transcripts (splice variants), 237 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in genital fat pad adult (RPKM 5.9), spleen adult (RPKM 5.8) and 28 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in retinal bipolar neuron differentiation. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Is active in nucleus. Is expressed in brain; liver; and renal vasculature. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Apr 2022]

Zhx2 Products (1)

mRNA Protein Name
NM_199449.2 NP_955520.1 zinc fingers and homeoboxes protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8939998 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mRNA catabolic process IDA
IDA: Inferred from direct assay
1370712 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
19515908 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19515908 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10673330 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
19515908 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
7523852 MGI
involved in retinal bipolar neuron differentiation IMP
IMP: Inferred from mutant phenotype
30146259 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
19515908 MGI
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
17056598 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19515908 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Zhx2 Protein Structure

zf_C2H2_ZHX

zf_C2H2_ZHX: pfam18387 (105 - 157)

homeodomain

homeodomain: cd00086 (271 - 320)

homeodomain

homeodomain: cd00086 (443 - 495)

HOX

HOX: smart00389 (536 - 581)

homeodomain

homeodomain: cd00086 (635 - 683)

  • 0
  • 200
  • 400
  • 600
  • 836 a.a.
Protein Preferred Names Protein Names

zinc fingers and homeoboxes protein 2

  • AFP regulator 1

  • alpha fetoprotein regulation 1, adult

  • alpha-fetoprotein regulator 1

  • regulator of AFP

  • zinc finger and homeodomain protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16069 ZHX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16070 Zhx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16071 Zhx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zhx2 NCBI NCBI:22882