LRRC26 - leucine rich repeat containing 26 Gene

Also Known as CAPC; bA350O14.10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 389816

About LRRC26

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,168,758-137,170,051 (from NCBI)

This gene has 1 transcript (splice variant), 283 orthologues and 22 paralogues. Biased expression in prostate (RPKM 24.0), colon (RPKM 13.3) and 1 other tissue.

Summary

Enables Potassium Channel activator activity; transmembrane transporter binding activity; and voltage-gated Potassium Channel activity. Involved in positive regulation of voltage-gated Potassium Channel activity and potassium ion transmembrane transport. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. [provided by Alliance of Genome Resources, Apr 2022]

LRRC26 Products (1)

mRNA	Protein	Name
NM_001013653.3	NP_001013675.1	leucine-rich repeat-containing protein 26 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables potassium channel activator activity	IDA IDA: Inferred from direct assay	22547800	GOA
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	20613726	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20613726	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22547800	GOA
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	22547800	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	22547800	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	22547800	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22547800	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	20613726	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC26 Protein Structure

LRR_8

0
100
200
300
334 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat-containing protein 26	BK channel auxiliary gamma subunit LRRC26

LRRC26 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRRC26	Q2I0M4	KCNMA1	Homo sapiens	Q12791	Anti Bait CoIP	20613726
Intra	LRRC26	Q2I0M4	KCNMA1	Homo sapiens	Q12791-5	Anti Bait CoIP	20613726

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07813	LRRC26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LRRC26	VGNC	VGNC:42792
Rattus norvegicus	LRRC26	RGD	RGD:1308398
Mus musculus	LRRC26	MGD	MGI:2385129
Felis catus	LRRC26	VGNC	VGNC:102950
Bos taurus	LRRC26	VGNC	VGNC:54445
Others	LRRC26	NCBI